分子細胞薬理学分野

Sawa Y, Saito M, Ishida N, Ibi M, Matsushita N, Morino Y, Taira E, Hirose M.
Pretreatment with KGA-2727, a Selective SGLT1 Inhibitor, is Protective against Myocardial Infarction-Induced Ventricular Remodeling and Heart Failure in Mice.
J Pharmacol Sci, in press.

Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Morino Y, Taira E, Taniguchi S, Iwakura Y, Sawa Y, Hirose M.
IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice.
Biol Pharm Bull, 42(4), 543-546, 2019

Hirose, M.
Current Topics ~ Inflammation and Tissue Remodeling as Potential Therapeutic Targets~ Foreword.
Biol Pharm Bull, 42(4), 517, 2019

Matsushita N, Ishida N, Ibi M, Saito M, Sanbe A, Shimojo H, Suzuki S, Koepsell H, Takeishi Y, Morino Y, Taira E, Sawa Y, Hirose M.
Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.
Int Heart J, 59(5): 1123-1133, 2018

弘瀬 雅教, 松下 尚子, 石田 菜々絵, 衣斐 美歩, 斎藤 麻希.
心筋リモデリングと Na+/グルコース共輸送体タンパク1(SGLT1).
Yakugaku Zasshi, 138(7): 939-943, 2018

Takizawa N*, Okubo N*, Kamo M, Chosa N, Mikami T, Suzuki K, Yokota S, Ibi M, Ohtsuka M., Taira M., Yaegashi T., Ishisaki A., Kyakumoto S. (*co-first authors)
Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture.
Exp Cell Res, 358:411-420, 2017.

Ueno M, Suzuki J, Hirose M, Sato S, Imagawa M, Zenimaru Y, Takahashi S, Ikuyama S, Koizumi T, Konoshita T, Kraemer FB, Ishizuka T.
Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase.
Am J Physiol Endocrinol Metab, 313: E699–E709, 2017.

Ibi M., Horie S., Kyakumoto S., Chosa N., Yoshida M., Kamo M., Ohtsuka M., Ishisaki A.
Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint.
Biosci Rep, 38(2), pii: BSR20171217. doi: 10.1042/BSR20171217, 2018

Inomata Y, Nagasaka S, Miyate K, Goto Y, Hino C, Toukairin C, Higashio R, Ishida K, Saino T, Hirose M, Tsumura H, Sanbe A.
Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart.
Biochem Biophys Res Commun. 496(4):1141-1147, 2018

Yamada H, Kikuchi S, Hakozaki M, Motodate K, Nagahora N, Hirose M. 8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice.
J Lipids, article ID7498508, 2016