神経科学分野

Liu,S., Ando F., Fujita Y., Liu J., Maeda T., Shen X., Kikuchi K., Matsumoto A., Yokomori M.,
Tanabe-Fujimura C., Shimokata H., Michikawa M., Komano H., and Zou, K.:A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’sdisease pathology in mice
J. Biol. Chem. 294:9760-9770, 2019

Shen X., Liu J., Fujita Y., Liu,S., Kikuchi K., Maeda T., Sera K., Michikawa M., Komano H., and Zou, K. :Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/ Aβ40 ratio.
Biochem. Biophys. Res. Commun. 512:653-658, 2019.

Maeda T, Fujita Y, Fujimura,C, Zou K., Liu,J., Liu,S.,Kikuchi,K, Shen X., Nakajima T., Komano H. :An E3 ubiquitin ligase, synoviolin, is involved in the degradation of homocysteine-inducible endoplasmic reticulum protein.]
Biol.& Pharm. Bull. 41:915-919, 2018

Fujita Y, Maeda T, Kamaishi K, Saito R, Chiba K, Shen X, Zou K, Komano H.:Expression of MEGF10 in cholinergic and glutamatergic neurons.
Neurosci. Lett. 653:25-30, 2017

Liu S., Liu J., Miura Y., Tanabe-Fujimura C., Maeda T., Terayama T., Turner A. J., Zou K., Komano H., :Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.
J Neurosci Res. 92:1178-1186, 2014

Maeda T, Inagaki M, Fujita Y, Kimoto T, Tanabe-Fujimura C, Zou K, Liu J, Liu S, Komano H.:ATP increases the migration of microglia across the brain endothelial cell monolayer.
Biosci. Rep. 36:2, 2016

Liu J., Liu S., Matsumoto Y., Murakami S., Sugakawa Y., Kami A., Tanabe C., Maeda T., Michikawa M, Komano H., and Zou K.:Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology
Sci. Rep., 5:12059, 2015

Liu J., Liu S., Tanabe-Fujimura C., Maeda T., Zou K., Komano H. :Differential effects of angiotensin II receptor blockers on Aβ generation.
Neurosci Lett. 567:51-56, 2014

菊池 光太, 藤田 融, 芦立 和之, 菊池 拓也, 菊池 結, 鄒 鶤, 駒野 宏人
アンギオテンシン受容体およびアドレナリンβ受容体間の相互作用によるアミロイドβタンパク産生制御の解析 日本生化学大会 東北支部 第84回例会・シンポジウム 岩手医科大学矢巾キャンパス 平成30年5月19日

Kun Zou, Xuefeng Shen, Kota Kikuchi, Arshad Noorani, Sadequl Islam, Makoto Michikawa, Hiroto Komano.
Iron-treatment enhances γ-secretase activity and inhibits amyloid deposition.
第37回日本認知症学会学術集会 札幌 平成30年10月12日