薬物代謝動態学分野

Onodera R, Jimma Y, Suzuki A, Habano W, Ozawa S, Terashima J.
The Regulation Pathway of VEGF Gene Expression Is Different between 2D Cells and 3D Spheroids in Human Lung Cancer Cells.
Biol Pharm Bull. 2023;46(4):608-613.

Habano W, Miura T, Terashima J, Ozawa S.
Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway.
Toxicology. 2022 Mar 30;470:153154.

Miura T, Onodera R, Terashima J, Ozawa S, Habano W.
β-naphthoflavone-induced upregulation of CYP1B1 expression is mediated by the preferential binding of aryl hydrocarbon receptor to unmethylated xenobiotic responsive elements.
Exp Ther Med. 2021 Dec;22(6):1410.

Ozawa S, Miura T, Terashima J, Habano W.
Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review
Cancer Drug Resist. 2021 Nov 2;4(4):946-964.

Ozawa S, Miura T, Terashima J, Habano W, Ishida S.
Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture.
Drug Metab Lett. 2021;14(1):25-40.

Ishikawa T, Terashima J, Sasaki D, Shimoyama Y, Yaegashi T, Sasaki M.
Establishment and use of a three-dimensional ameloblastoma culture model to study the effects of butyric acid on the transcription of growth factors and laminin β3.
Arch Oral Biol. 2020 Oct;118:104845.

Ishikawa T, Terashima J, Shimoyama Y, Ohashi Y, Mikami T, Takeda Y, Sasaki M.
Effects of butyric acid, a bacterial metabolite, on the migration of ameloblastoma mediated by laminin 332.
J Oral Sci. 2020 Sep 26;62(4):435-438.

Jimma Y, Jimma K, Yachi M, Hakata S, Habano W, Ozawa S, Terashima J.
Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids.
Cancer Invest. 2019;37(8):367-375.

Terashima J, Jimma Y, Jimma K, Hakata S, Yachi M, Habano W, Ozawa S.
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
Drug Metab Pharmacokinet. 2018 Aug;33(4):211-214.

Hakata S, Terashima J, Shimoyama Y, Okada K, Fujioka S, Ito E, Habano W, Ozawa S.
Differential sensitization of two human colon cancer cell lines to the antitumor effects of irinotecan combined with 5-aza-2'-deoxycytidine.
Oncol Lett. 2018 Apr;15(4):4641-4648.