薬物代謝動態学分野

Terashima J, Sampei S, Iidzuka M, Ohsakama A, Tachikawa C, Satoh J, Kudo K, Habano W, Ozawa S.
VEGF expression is regulated by HIF-1α and ARNT in 3D KYSE-70, esophageal cancer cell spheroids.
Cell Biol Int. 2016 Nov;40(11):1187-1194.

Okada K, Hakata S, Terashima J, Gamou T, Habano W, Ozawa S.
Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.
Oncol Rep. 2016 Oct;36(4):1875-85.

Terashima J, Goto S, Hattori H, Hoshi S, Ushirokawa M, Kudo K, Habano W, Ozawa S.
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
Drug Metab Pharmacokinet. 2015 Dec;30(6):434-40.

Habano W, Kawamura K, Iizuka N, Terashima J, Sugai T, Ozawa S.
Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes.
Clin Epigenetics. 2015 Sep 28;7:105.

Gamou T, Habano W, Terashima J, Ozawa S.
A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
Drug Metab Pharmacokinet. 2015 Apr;30(2):188-97.

Terashima J, Tachikawa C, Kudo K, Habano W, Ozawa S.
An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2.
BMC Mol Biol. 2013 Dec 12;14:27.

Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.
BMC Cancer. 2011 Feb 22;11:81.

Terashima J, Habano W, Gamou T, Ozawa S.
Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR.
Drug Metab Pharmacokinet. 2011;26(6):577-83.