天然物化学分野

Isao Fujii, Makoto Hashimoto, Kaori Konishi, Akiko Unezawa, Haruka Sakuraba, Kenta Suzuki, Harue Tsushima, Miho Iwasaki, Satsuki Yoshida, Akane Kudo, Rina Fujita, Aika Hichiwa, Koharu Saito, Takashi Asano, Jun Ishikawa, Daigo Wakana, Yukihiro Goda, Ayumi Watanabe, Mamoru Watanabe, Yui Masumoto, Junichiro Kanazawa, Hajime Sato, Masanobu Uchiyama: Functional Analysis of a Biosynthetic Gene Cluster Demonstrates Role of Spontaneous Double Bicyclo‐ring Formation Including 8π–6π Electrocyclization in Shimalactone Biosynthesis. Angew. Chem. Int. Ed., 59, 8464-8470 (2020).

Makoto Hashimoto, Hitomi Ichijo, Kotaro Fujiwara, Hitoshi Sugasawa, Seika Abo, Kimihito Matsudo, Nahoko Uchiyama, Yukihiro Goda, Isao Fujii: Functional expression of a highly-reducing polyketide synthase of Emericella variecolor IFM42010, an asteltoxin-producing strain, resulted in production of two polyenoic β-ketolactones with opposite stereochemistry. Bioorg. Med. Chem. Lett., 29, 126686 (2019).

Ryo Nakabayashi, Tomoko Nishizawa, Tetsuya Mori, Hiroshi Sudo, Isao Fujii, Takashi Asano, Kazuki Saito: Evaluating the sulfur-containing metabolite asparaptine in Asparagus calluses and a suspension cell line by untargeted metabolome analysis using liquid chromatography tandem mass spectrometry. Plant Biotech., 36, 265-267 (2019).

Hiroaki Hayashi, Musavvara Shukurova, Shihoko Oikawa, Minami Ohta, Isao Fujii, Firuza Nasyrova, Kurbon Aliev, Hikmat Hisoriev, Inoyat Fattokhov, Madibron Saidov: Field Survey of Ephedra Plants in Central Asia (1). Characterizationof Ephedra equisetina, Ephedra intermedia, and Their Putative Hybrids. Biol. Pharm. Bull., 42, 552-556 (2019).

Yuhta Nomura, Hikaru Seki, Tomonori Suzuki, Kiyoshi Ohyama, Masaharu Mizutani, Tomomi Kaku, Keita Tamura, Eiichiro Ono, Manabu Horikawa, Hiroshi Sudo, Hiroaki Hayashi, Kazuki Saito, Toshiya Muranaka: Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin. Plant J., 99, 1127–1143 (2019).

Hiroaki Hayashi, Keiko Yokoshima, Ren Chiba, Isao Fujii, Inoyat Fattokhov, Madibron Saidov: Field Survey of Glycyrrhiza Plants in Central Asia (5). Chemical Characterization of G. bucharica Collected in Tajikistan. Chem. Pharm. Bull, 67, 534-539 (2019).

Mio Kawaguchi, Taichi Ohshiro, Masayuki Toyoda, Satoshi Ohte, Junji Inokoshi, Isao Fujii, Hiroshi Tomoda: Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers. Angewandte Chemie Int. Edt., 57, 5115-5119 (2018).

Ayako Katsuki, Hikaru Kato, Yurika Tahara, Makoto Hashimoto, Isao Fujii, Sachiko Tsukamoto: pH-Dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C. Bioorg. Med. Chem., 26, 1869-1874 (2018).

Makoto Hashimoto, Hikaru Kato, Ayako Katsuki, Sachiko, Tsukamoto, Isao Fujii: Identification of the biosynthetic gene cluster for himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor, in Aspergillus japonicus. ChemBioChem, 19, 535-539 (2018).