情報薬科学分野

Yonezawa, H., Ogawa, M., Katayama, S., Shimizu, Y., Omori, N., Oku, Y., Sakyo, T., Uehara, Y., Nishiya, N. Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: the heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase. Biochem. Biophys. Res. Commun., 506(1): 183-188 (2018)

Oku, Y., Nishiya, N., Sugiyama, S., Sato, H., Uehara, Y. Sensitisation of cancer cells to MLN8237, an Aurora-A inhibitor, by YAP/TAZ inactivation. Anticancer Res., 38: 3471-3476 (2018)

Oku, Y., Nishiya, N., Tazawa, T., Kobayashi, T., Umezawa, N., Sugawara, Y., Uehara, Y. Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP–E2F1–DNA damage response pathway axis. FEBS Open Bio, 8(6):1001-1012 (2018) doi: 10.1002/2211-5463.12440

Fukuda T., Umeki T., Tokushima K., Xiang G., Yoshida Y., Ishibashi F., Oku Y., Nishiya N., Uehara Y., Iwao, M. Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant. Bioorg. Med. Chem., 25(24): 6563-6580 (2017)

Oku, Y.*, Nishiya, N.*, Tsuda, K., Shibazaki, M., Maesawa, C., Uehara, Y. Dynamic phenotypic transition of breast cancer cells in vitro revealed by self-floating cell culture. Anticancer Res., 37(4): 1793-1797 (2017) *co-first author

西谷直之「ゼブラフィッシュ胚を用いた薬剤スクリーニングと薬力学的相互作用の予測」医薬品相互作用研究、43(1): 1-8 (2019)

Nishiya, N. Screening for Chemical Suppressor of the Wnt/β-catenin Signaling Pathway, Yakugaku-Zasshi, 137(2):133-136 (2017)

西谷直之、奥裕介「ゼブラフィッシュ・表現型基盤型薬剤スクリーニングへの応用」生体の科学、68(1): 74-79 (2017)

西谷直之「トポイソメラーゼ阻害剤ラメラリンの標的指向性変換による薬剤耐性EGFR阻害剤の創出」日本がん分子標的治療学会 第14回TRワークショップ「低分子抗がん剤開発最前線~アカデミアの夢、企業の現実」、東京(2019年1月18日)

Nishiya, N., Yonezawa, H., Sakyo, T.「Chemical suppressors of the Wnt/β-catenin signaling pathway and their molecular targets」2018 The 6th Tripartite Conference on Tooth and Bone in Development & Regeneration, Hong Kong (2018年8月18日)