Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M.
Cardiac overexpression of constitutively active Gαq causes angiotensin II type 1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
PLoS One. 9 (8): e106354, 2014
分子細胞薬理学分野
Matsushita N, Hirose M, Sanbe A, Kondo Y, Irie Y, Taira E.
Nicorandil improves electrical remodeling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy.
Clin Exp Pharmacol Physiol. 41(1):89-97, 2014
Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongo M, Yamada M.
β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.
Eur J Pharmacol. 724:122-31, 2014
Yoshihara T, Yonoki Y, Saito M, Nakahara T, Sakamoto K, Ishii K.
Agonist-induced receptor internalization in Chinese hamster ovary cells stably co-expressing β1- and β2-adrenergic receptors.
Biol Pharm Bull. 36(1):114-9, 2013
Misaka T, Suzuki S, Miyata M, Kobayashi A, Shishido T, Ishigami A, Saitoh S, Hirose M, Kubota I, Takeishi Y.
Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.
Cardiovasc Res.99(3):461-70, 2013
Laurita KR, Hirose M.
Electrical vagal stimulation and cardioprotection.
Heart Rhythm. 10(11):1708-9, 2013
松下 尚子、平 英一、弘瀬 雅教、阿南 如子、三部 篤.
デスミン関連心筋症で誘発される不整脈に対するニコランジルの改善作用メカニズム.
Ther Res 34:293-295, 2013
Hirose M, Matsushita N.
A new therapeutic approach for postoperative systemic inflammation: Effectiveness of epicardial ganglionated plexus stimulation.
Heart Rhythm. 9:951-952, 2012
Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M.
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Am J Physiol Heart Circ Physiol 302:H1645-H1654, 2012
Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation.
Eur J Pharmacol., 685:15-23, 2012